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Optimal Therapeutic Window Model of Interferon alpha and Imatinib in Combination Therapy in CML Patients
Chronic Myeloid Leukemia is a type of cancer that starts in certain blood-forming cells of the bone marrow. Interferon-\(\alpha\) was once the standard front-line treatment producing remission rates of only 28.3 percent in 1991. After the highly effective drugs first became available in 2001, survival rates have increased immensely. According to the American Cancer Society, one large study of CML patients treated with a drug called imatinib found that about 90 percent of them were still alive 5 years after starting treatment. While imatinib has changed the way oncologists treat CML, remission is common after extended gaps in treatment. In this paper, we will explore the long-term dynamics of CML under treatment through the use of use of theoretical and mathematical components. We closely base our methods upon the approach of Urszula Ledzewicz and Helen Moore. We will introduce our unique model and explain component selections, while we move towards understanding the optimal interactions of imatinib and interferon-\(\alpha\) against dormant and proliferating CML cells. Our future work involving optimal control dynamics will be briefly introduced and further solutions are currently ongoing.
Introducción a MATLAB
En el presente post, haremos una breve introducción de la herramienta MATLAB. Presentaremos funciones, operaciones y gráficos con más de dos datos, para asi luego ordenar y hacer cálculos con matrices.
Benjamin Pastene Rebolledo
Programacióon Bajo Plataformas Abiertas Laboratorio 2
Este reporte tiene como objetivo principal conocer y comprender los comandos relacionados con el manejo de archivos y directorios, además de aquellos relacionados con el tema de rutas relativas y absolutas, listar contenidos y copiar texto entre archivos. El laboratorio se realiza a partir de las instrucciones dadas por el profesor, en las cuales se detalla cada paso y estos serán explicados en la sección de análisis de resultados. El manejo de estos comandos es importante para seguir comprendiendo los fundamentos básicos de la consola de Linux aprendidos en las primeras semanas de clases, con el fin de aplicarlos como un conjunto en un futuro.
The kernel is a computer program that has complete control over the operating system. It handles the input/output requests and translates them into data-processing instructions for the CPU. It handles not only the memory, but also peripherals.
The kernel controls the tasks that are managed in the running system, some of these are running processes, hardware management and handling interrupts, in the kernel space. On the other hand, the user performs in the user space. This separation helps to prevent data interfering that can cause instability and slowness, or worse, malfunctioning application programs that can crash the entire operating system.
The process scheduler decides which is the next task to run. In the following project we analyzed the behavior of the scheduler changing the default value of the runtime scheduling, this value is 950000µs for the scheduler real time running variable. According to this, 5% of the CPU time is reserved for processes that are not running under a realtime or deadline scheduling policy. On this project, this value specifies how much of the period time could be used by real-time and deadline scheduled processes on the system.
Propagation of thermal diffusive waves in a metal by Fourier analysis
Thermal wave phenomenon is observed is thin metallic rod by application of periodic heating. In this way, it is demonstrated that there is no wave nature in these improperly called thermal waves by showing that they do not transport energy and its propagation properties can be used to determine the thermal diffusivity of the material.
syed waqar ahmed