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Designing a Drug to Inhibit Death-Associated Protein Kinase 1's Catalytic Activity
Designing a Drug to Inhibit Death-Associated Protein Kinase 1's Catalytic Activity
Final Project for Drug Design and Discovery class.
Paula Godoy
Engineering Fasciculin-II to treat Alzheimer's Disease Related Symptoms
Engineering Fasciculin-II to treat Alzheimer's Disease Related Symptoms
Alzheimer’s disease is characterized by death of cholinergic neurons, which secrete the neurotransmitter acetylcholine. This results in a loss of the total amount of acetylcholine circulating in neural networks. Modern drugs target acetylcholinesterase so as to inhibit its function, allowing for increased transmission of acetylcholine in cholinergic synapses. The aim is that an increase in cholinergic activity leads to an increase in cognition. However, these drugs only bind temporarily and have consequential problems that make modern AChE inhibitors of little effect. The main goal of our project is to engineer a snake toxin, fasciculin-II, capable of crossing the blood brain barrier and inhibiting acetylcholinesterase with enough affinity that it increases cholinergic transmission without yielding toxic outcomes. This fasciculin binds to the peripheral acetylcholinesterase found in neuromuscular junctions and causes rapid twitching. Fasciculin-II binds to acetylcholinesterase very tightly with the use of many charged residues and hydrophobic residues and we would like to optimize this interaction so that it may serve a therapeutic purpose in patients of AD.
Paula
Sample Wallplanner
Sample Wallplanner
Wallplanner for Aug to Oct 2014 latex source generated using https://github.com/perl2ruby/wallplanner/blob/master/wallplanner.rb, output of: ./wallplanner.rb 2014 8..10 requires baposter.cls available here (http://www.brian-amberg.de/uni/poster/baposter/baposter.cls) changed snakes to decorations in baposter.cls
Rangarajan R
Plantilla Tesis LRM
Plantilla Tesis LRM
Tesis de Maestria en Electrica.
Pedro PATLAN
Lógica Difusa
Lógica Difusa
Beamer - DICIS-UG
Pedro PATLAN
Template FIN/TC/MD
Template FIN/TC/MD
Private template for my team work
Mohamed Ramzi
Drawing Pie Charts with pgf-pie
Drawing Pie Charts with pgf-pie
pgf-pie is a LaTeX package for drawing pie charts (and some interesting variants on pie charts) with the PGF/TikZ graphics package. The examples in this document are from the pgf-pie manual, version 0.2. The source code for pgf-pie is available at http://code.google.com/p/pgf-pie/.
Yuan Xu
Language Science Press Presentation
Language Science Press Presentation
The presentation template for Language Science Press presentations.
Sebastian Nordhoff
High-Speed Digital PCB Project
High-Speed Digital PCB Project
In this experiment I looked into a way fo measuring the ground bounce generated by capacitively loading 5 outputs of a Texas Instrument small outline package Hex-Flip Flop chip and discharging them all simultaneously.
kdrobers